This talk was presented at The National Abilities Center on September 20, 2018 and at The Autism Educational Summit on September 29, 2018
Summary
This talk will focus on barriers that can block and impact the road to recovery. The first barrier is the complexity of autism. We will start by acknowledging the complexity of the genetics, environmental factors, and the symptoms of autism. Then, several concepts will be introduced to organize and radically simplify how we think about autism. The talk will review a list of known and suspected environmental factors, as well as practical ways you can start to reduce your exposures. There will be an emphasis on reducing exposures to wireless and EMF (electromagnetic fields), since these rapidly growing exposures and their health impacts are not generally well understood by parents and healthcare professionals.
Download the audio: Simplifying Autism: Removing Barriers
Follow along with the slides: Simplifying Autism: Removing Barriers
References
About Clear Light Ventures and Peter Sullivan
Hallmayer, Joachim, et al. "Genetic heritability and shared environmental factors among twin pairs with autism." Archives of general psychiatry 68.11 (2011): 1095-1102.
Herbert, Martha, and Karen Weintraub. The Autism Revolution: whole-body strategies for making life all it can be. Ballantine Books, 2013.
NIH: Autism Spectrum Disorder: Genetics
[9] Wen, Ya, Mohamad J. Alshikho, and Martha R. Herbert. “Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Convergence upon MAPK and Calcium Signaling.” Plus one 11.4 (2016): e0153329.
Martin Pall “EMFs and Chemicals as the Two Main Drivers of the Autism Epidemic: Mechanisms of Action”
Wu, Jianping, et al. "Structure of the voltage-gated calcium channel Cav1. 1 complex." Science 350.6267 (2015): aad2395.
Büsselberg, Dietrich. "Calcium channels as target sites of heavy metals."Toxicology letters 82 (1995): 255-261.
De Novo Mutations - account for 50% of autism cases
Does autism arise because the brain is continually surprised?
Lozac, N. B. S. "Central role of voltage gated calcium channels and intercellular calcium homeostasis in autism." (2010)
Feske, Stefan. "Ca2+ influx in T cells: How many Ca2+ channels?." Frontiers in immunology 4 (2013): 99.
Herbert, Martha R., and Cindy Sage. "Autism and EMF? Plausibility of a pathophysiological link–Part I."Pathophysiology 20.3 (2013): 191-209.
Herbert, Martha R., and Cindy Sage. "Autism and EMF? Plausibility of a pathophysiological link Part II."Pathophysiology 20.3 (2013): 211-234.
Faber, Scott, et al. "A clean room sleeping environment’s impact on markers of oxidative stress, immune dysregulation, and behavior in children with autism spectrum disorders." BMC complementary and alternative medicine 15.1 (2015): 71.
Naviaux, Robert K. "Metabolic features of the cell danger response." Mitochondrion 16 (2014): 7-17.
Environmental Factor References
The Environmental and Genetic Causes of Autism (2016) by James Lyons-Weiler
Ng, Michelle, et al. "Environmental factors associated with autism spectrum disorder: a scoping review for the years 2003-2013." Chronic Diseases and Injuries in Canada 37.1 (2017).
Rossignol, D. A., S. J. Genuis, and R. E. Frye. "Environmental toxicants and autism spectrum disorders: a systematic review." Translational psychiatry 4.2 (2014): e360.
Landrigan, Philip J., Luca Lambertini, and Linda S. Birnbaum. "A research strategy to discover the environmental causes of autism and neurodevelopmental disabilities." (2001).
Raz, Raanan, et al. "Autism spectrum disorder and particulate matter air pollution before, during, and after pregnancy: a nested case–control analysis within the Nurses’ Health Study II cohort." (2014).
Calderón-Garcidueñas, Lilian, et al. "Air pollution and detrimental effects on children’s brain. The need for a multidisciplinary approach to the issue complexity and challenges." Frontiers in human neuroscience 8 (2014).
Cavalli, Vera Lúcia de Liz Oliveira, et al. "Roundup disrupts male reproductive functions by triggering calcium-mediated cell death in rat testis and Sertoli cells." Free Radical Biology and Medicine 65 (2013): 335-346.
Fluegge, Keith. "Autism in 2016: additional discovery." Jornal de Pediatria (2016).
Faber, Scott, et al. "A cleanroom sleeping environment’s impact on markers of oxidative stress, immune dysregulation, and behavior in children with autism spectrum disorders." BMC complementary and alternative medicine 15.1 (2015): 1.
Adams, James B., et al. "Mercury, lead, and zinc in baby teeth of children with autism versus controls." Journal of Toxicology and Environmental Health, Part A 70.12 (2007): 1046-1051.
Geier, David A., Janet K. Kern, and Mark R. Geier. "A prospective study of prenatal mercury exposure from maternal dental amalgams and autism severity." Acta Neurobiol Exp (Wars) 69.2 (2009): 189-97.
Mohamed, Farida El Baz, et al. "Assessment of hair aluminum, lead, and mercury in a sample of autistic Egyptian children: environmental risk factors of heavy metals in autism." Behavioural neurology 2015 (2015).
Carrascosa-Romero, Maria Carmen, and Carlos De Cabo-De La Vega. "The Genetic and Epigenetic Basis Involved in the Pathophysiology of ASD: Therapeutic Implications." Autism-Paradigms, Recent Research and Clinical Applications. InTech, 2017.
Karimi, Padideh, et al. "Environmental factors influencing the risk of autism." Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences 22 (2017).
Modabbernia, Amirhossein, Eva Velthorst, and Abraham Reichenberg. "Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses." Molecular Autism 8.1 (2017): 13.
Ng, Michelle, et al. "Environmental factors associated with autism spectrum disorder: a scoping review for the years 2003-2013." Chronic Diseases and Injuries in Canada 37.1 (2017).
Jyonouchi, Harumi. "Food allergy and autism spectrum disorders: is there a link?." Current allergy and asthma reports 9.3 (2009): 194-201.
Jim West “Ultrasound: A New Bibliography Human Studies Indicate Extreme Risk”
Mark Zylka, “Exploiting genetics to identify environmental risks for autism”
Rossignol, D. A., S. J. Genuis, and R. E. Frye. "Environmental toxicants and autism spectrum disorders: a systematic review." Translational psychiatry 4.2 (2014): e360.
De Cock, Marijke, Yolanda GH Maas, and Margot van de Bor. "Does perinatal exposure to endocrine disruptors induce autism spectrum and attention deficit hyperactivity disorders? Review." Acta paediatrica 101.8 (2012): 811-818.
Lichtensteiger, Walter, et al. "Differential gene expression patterns in developing sexually dimorphic rat brain regions exposed to antiandrogenic, estrogenic, or complex endocrine disruptor mixtures: glutamatergic synapses as target." Endocrinology 156.4 (2015): 1477-1493.
Samsel A, Seneff S. Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies. Surg Neurol Int 24-Mar-2015;6:45
Herbert, Martha R., and Cindy Sage. "Autism and EMF? Plausibility of a pathophysiological link–Part I." Pathophysiology 20.3 (2013): 191-209.
Herbert, Martha R., and Cindy Sage. "Autism and EMF? Plausibility of a pathophysiological link Part II." Pathophysiology 20.3 (2013): 211-234.
Pall, M.L., Microwave frequency electromagnetic fields (EMFs) produce widespread neuropsychiatric effects including depression, Journal of Chemical Neuroanatomy (2015).
Pall, M.L., The Autism Epidemic Is Caused by EMFs, Acting via Calcium Channels and Chemicals Acting via NMDA-Rs: Downstream Effects Cause Autism (Conference Presentation). 2015.
Pall, Martin L. "Electromagnetic fields act via activation of voltage‐gated calcium channels to produce beneficial or adverse effects." Journal of cellular and molecular medicine 17.8 (2013): 958-965.
Waldman, Michael, Sean Nicholson, and Nodir Adilov. Does Television Cause Autism?. No. w12632. National Bureau of Economic Research, 2006.
Victoria L. Dunckley MD “Reset Your Child's Brain: A Four-Week Plan to End Meltdowns, Raise Grades, and Boost Social Skills by Reversing the Effects of Electronic Screen” (2015)
Jia, Feiyong, et al. "Core symptoms of autism improved after vitamin D supplementation." Pediatrics 135.1 (2015): e196-e198.
Corbett, Blythe A., et al. "Cortisol circadian rhythms and response to stress in children with autism." Psychoneuroendocrinology 31.1 (2006): 59-68.
Frisch, Morten, and Jacob Simonsen. "Ritual circumcision and risk of autism spectrum disorder in 0-to 9-year-old boys: national cohort study in Denmark." Journal of the Royal Society of Medicine (2015): 0141076814565942.
Bauer, Ann Z., and David Kriebel. "Prenatal and perinatal analgesic exposure and autism: an ecological link." Environ Health 12.1 (2013): 41.
Jane Webb, Sara, et al. "Severity of ASD symptoms and their correlation with the presence of copy number variations and exposure to first trimester ultrasound." Autism Research (2016).
Thomas, David. "A study on the mineral depletion of the foods available to us as a nation over the period 1940 to 1991." Nutrition and Health 17.2 (2003): 85-115.
Mayer, Anne-Marie. "Historical changes in the mineral content of fruits and vegetables." British Food Journal 99.6 (1997): 207-211.